von Giesen H J, Bäcker R, Hefter H, Arendt G
Department of Neurology, Heirich Heine University, Duesseldorf, Germany.
J Neuropsychiatry Clin Neurosci. 2001 Winter;13(1):88-94. doi: 10.1176/jnp.13.1.88.
The authors examined the effects of depressive mood (Hamilton Rating Scale for Depression [Ham-D]) on basal ganglia-mediated psychomotor speed (motor test battery) in 202 HIV-1 seropositive homosexual males with no prior history of antiretroviral treatment. HIV-1 seropositive patients showed a significant slowing of most rapid alternating movements (MRAM) and significantly prolonged contraction times (CT) compared with 66 HIV-1 seronegative male control subjects. Factor analysis of Ham-D scores isolated a factor containing the items depressed mood, suicide, and psychic and somatic anxiety. This factor did not correlate with MRAM or CT. Depression and psychomotor speed are independent in HIV-1infection.
作者研究了抑郁情绪（汉密尔顿抑郁量表[Ham-D]）对202名无抗逆转录病毒治疗史的HIV-1血清阳性同性恋男性基底神经节介导的精神运动速度（运动测试组合）的影响。与66名HIV-1血清阴性男性对照受试者相比，HIV-1血清阳性患者的大多数快速交替运动（MRAM）显著减慢，收缩时间（CT）显著延长。对Ham-D评分进行因子分析，分离出一个包含情绪低落、自杀以及精神和躯体焦虑项目的因子。该因子与MRAM或CT均无相关性。在HIV-1感染中，抑郁与精神运动速度是独立的。
