Oshima H, Rochat A, Kedzia C, Kobayashi K, Barrandon Y
Department of Biology, Ecole Normale Supérieure, 46 rue d'Ulm, 75230 Cedex 05, Paris, France.
Cell. 2001 Jan 26;104(2):233-45. doi: 10.1016/s0092-8674(01)00208-2.
The upper region of the outer root sheath of vibrissal follicles of adult mice contains multipotent stem cells that respond to morphogenetic signals to generate multiple hair follicles, sebaceous glands, and epidermis, i.e., all the lineages of the hairy skin. At the time when hair production ceases and when the lower region of the follicle undergoes major structural changes, the lower region contains a significant number of clonogenic keratinocytes, and can then respond to morphogenetic signals. This demonstrates that multipotent stem cells migrate to the root of the follicle to produce whisker growth. Moreover, our results indicate that the clonogenic keratinocytes are closely related, if not identical, to the multipotent stem cells, and that the regulation of whisker growth necessitates a precise control of stem cell trafficking.
成年小鼠触须毛囊外根鞘的上部区域含有多能干细胞，这些干细胞对形态发生信号作出反应，以生成多个毛囊、皮脂腺和表皮，即多毛皮肤的所有谱系。在毛发停止生长以及毛囊下部区域发生重大结构变化时，下部区域含有大量克隆形成性角质形成细胞，然后能够对形态发生信号作出反应。这表明多能干细胞迁移到毛囊根部以促进须毛生长。此外，我们的结果表明，克隆形成性角质形成细胞即使与多能干细胞不完全相同，也密切相关，并且须毛生长的调节需要对干细胞迁移进行精确控制。
