Brouard Michel, Barrandon Yann
Laboratory of Stem Cell Dynamics, School of Life Sciences, Swiss Federal Institute of Technology Lausanne and Department of Experimental Surgery, Lausanne University Hospital, 1015 Lausanne, Switzerland.
Curr Opin Biotechnol. 2003 Oct;14(5):520-5. doi: 10.1016/j.copbio.2003.09.005.
To master tissue and organ morphogenesis necessitates a thorough understanding of the cellular and molecular events involved in development, renewal, repair and regeneration. Skin reconstruction is the paradigm of tissue engineering. The transplantation of autologous adult epidermal stem cells is a life-saving procedure as it regenerates the indispensable barrier function of the skin, but the reconstruction of fully functional skin has been hampered by the complexity of the process. The recent identification of multipotent epithelial stem cells in adult hair follicles and of multipotent stem cells in dermis raises new hopes.
要掌握组织和器官的形态发生，就必须深入了解发育、更新、修复和再生过程中涉及的细胞和分子事件。皮肤重建是组织工程的典范。自体成人表皮干细胞移植是一种挽救生命的手术，因为它能再生皮肤不可或缺的屏障功能，但全功能皮肤的重建因过程复杂而受到阻碍。最近在成人毛囊中发现多能上皮干细胞以及在真皮中发现多能干细胞，带来了新的希望。
