使用大剂量阿糖胞苷后发生中毒性表皮坏死松解症。
Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.
作者信息
Ozkan A, Apak H, Celkan T, Yüksel L, Yildiz I
机构信息
Cerrahpasa Medical Faculty, Department of Pediatric Hematology-Oncology, University of Istanbul, Istanbul, Turkey.
出版信息
Pediatr Dermatol. 2001 Jan-Feb;18(1):38-40. doi: 10.1046/j.1525-1470.2001.018001038.x.
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C). A 13-year-old girl with acute lymphocytic leukemia was treated according to the protocol of the BFM Group (BFM-95, HRG). On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day. ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.
我们报告了一例因高剂量阿糖胞苷（ARA-C）导致的中毒性表皮坏死松解症（TEN）致死病例。一名13岁急性淋巴细胞白血病女孩按照BFM组（BFM-95，HRG）方案进行治疗。在静脉注射高剂量阿糖胞苷（每12小时2 g/m²）后的第5天，她的手部和脚底出现水疱性病变，病变扩散，在第22天发展为坏死、败血症并死亡。阿糖胞苷常与皮肤毒性相关，但这是第二例与该药物相关的中毒性表皮坏死松解症病例。
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