高剂量阿糖胞苷是白血病患者发生肝脾念珠菌病的主要危险因素。

High dose cytosine arabinoside is a major risk factor for the development of hepatosplenic candidiasis in patients with leukemia.

作者信息

Woolley I, Curtis D, Szer J, Fairley C, Vujovic O, Ugoni A, Spelman D

机构信息

Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

出版信息

Leuk Lymphoma. 1997 Nov;27(5-6):469-74. doi: 10.3109/10428199709058313.

DOI:10.3109/10428199709058313

PMID:9477128

Abstract

A retrospective study of hepatosplenic candidiasis in patients with acute leukemia from a single centre was performed. The significance of age, sex, type of leukemia, dose of cytosine arabinoside (Ara-C), duration of neutropenia, steroid use and period of therapeutic antibiotics in the development of hepatosplenic candidiasis was analyzed, using logistic regression analysis. Nine of 51 patients had hepatosplenic candidiasis. Ara-C use was highly associated with the development of hepatosplenic candidiasis (p = 0.001); with a high association with a higher dose (p < 0.0001). On the basis of these results consideration should be given to further trial of antifungal prophylaxis for patients receiving high dose Ara-C.

摘要

对来自单一中心的急性白血病患者的肝脾念珠菌病进行了一项回顾性研究。使用逻辑回归分析，分析了年龄、性别、白血病类型、阿糖胞苷（Ara-C）剂量、中性粒细胞减少持续时间、类固醇使用情况以及治疗性抗生素使用时间在肝脾念珠菌病发生中的意义。51例患者中有9例发生肝脾念珠菌病。使用Ara-C与肝脾念珠菌病的发生高度相关（p = 0.001）；与较高剂量高度相关（p < 0.0001）。基于这些结果，应考虑对接受高剂量Ara-C的患者进一步进行抗真菌预防试验。