[使用中等剂量阿糖胞苷后发生的中毒性表皮坏死松解症]
[Toxic epidermal necrolysis after the use of intermediate dose of cytosine arabinoside].
作者信息
Figueiredo M S, Yamamoto M, Kerbauy J
机构信息
Departamento de Medicina, Universidade Federal de São Paulo-Escola Paulista de Medicina.
出版信息
Rev Assoc Med Bras (1992). 1998 Jan-Mar;44(1):53-5. doi: 10.1590/s0104-42301998000100011.
UNLABELLED
Toxic epidermal necrolysis is a drug-induced dermatologic disease related to Lyell syndrome, erythema multiforme and Stevens-Johnson syndrome.
PURPOSE
To report a fatal case of toxic epidermal necrolysis owing to intermediate dose of cytarabine.
CASE REPORT
A 16 year-old female patient with acute lymphocytic leukemia (LLA-L1) treated with the Protocol of the Brazilian Group for Treatment of Leukemia of Childwood (GBTLI-85-AR). On the second day after the administration of intermediate dose of cytarabine (1.5 g/m2 i.v. every 12 hours for 3 days), she presented bullous lesions in the left buttock that disseminated envolving to necrosis, sepsis, and death on the 13th day.
CONCLUSION
Cytarabine is frequently associated with dermatologic toxicity but, until now, there is no other case of toxic epidermal necrolysis described.
未标注
中毒性表皮坏死松解症是一种与莱尔综合征、多形红斑和史蒂文斯-约翰逊综合征相关的药物性皮肤病。
目的
报告一例因中等剂量阿糖胞苷导致中毒性表皮坏死松解症的致死病例。
病例报告
一名16岁急性淋巴细胞白血病（LLA-L1）女性患者，按照巴西儿童白血病治疗小组方案（GBTLI-85-AR）进行治疗。在给予中等剂量阿糖胞苷（1.5 g/m²静脉注射，每12小时一次，共3天）后的第二天，她左侧臀部出现大疱性皮损，皮损扩散并发展为坏死、败血症，于第13天死亡。
结论
阿糖胞苷常伴有皮肤毒性，但截至目前，尚未有其他中毒性表皮坏死松解症病例的描述。
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