Victoria J, Trujillo R
Department of Dermatology, School of Medicine, Universidad del Valle, Cali, Colombia.
Pediatr Dermatol. 2001 Jan-Feb;18(1):63-5. doi: 10.1046/j.1525-1470.2001.018001063.x.
Ivermectin is the only one of the avermectins that has been widely used in humans, since it is recommended as the treatment of choice for onchocerciasis, a filariasis that produces "river blindness," a parasitic endemic infestation in countries of West Equatorial Africa and in some areas of Central and South America. Also, ivermectin has been used for treating human endo- and ectoparasites with effective results and with almost no side effects. To study the efficacy of ivermectin for scabies, which is very common in Colombia, a trial with this drug that could be easily administered, with fast application and high efficacy, was undertaken. For this purpose, six complete families with active scabies, consisting of 12 adults and 20 children ranging in age from 1 to 10 years, were treated with 1% ivermectin in a solution of propylene glycol applied topically to the affected skin. The dose employed was 400 microg/kg, repeated once the following week. All patients were cured, tolerated the medication well, and there were no side effects or signs of recurrence 2, 4, or 6 weeks after therapy. In addition to its efficacy, easy administration, and lack of side effects, ivermectin is a low-cost medication.
伊维菌素是阿维菌素类药物中唯一已在人类中广泛使用的药物，因为它被推荐作为治疗盘尾丝虫病的首选药物，盘尾丝虫病是一种能导致“河盲症”的丝虫病，在赤道西非国家以及中美洲和南美洲的一些地区呈地方性寄生虫感染。此外，伊维菌素已用于治疗人体内外寄生虫，效果显著且几乎没有副作用。为研究伊维菌素对疥疮（在哥伦比亚非常常见）的疗效，开展了一项关于这种药物的试验，该药物易于给药、施用迅速且疗效高。为此，对六个患有活动性疥疮的完整家庭进行了治疗，这些家庭由12名成年人和20名年龄在1至10岁的儿童组成，采用1%伊维菌素的丙二醇溶液局部涂抹于受影响皮肤。使用的剂量为400微克/千克，下周重复一次。所有患者均治愈，对药物耐受性良好，治疗后2、4或6周均无副作用或复发迹象。除了疗效好、易于给药且无副作用外，伊维菌素还是一种低成本药物。
