Buresová O, Bures J
J Comp Physiol Psychol. 1975 Jan;88(1):47-52. doi: 10.1037/h0076188.
Conditioned taste aversion established in rats by association of saccharin drinking with subsequent lithium chloride intoxication decreased saccharin intake to 22% of normal consumption. Force-feeding saccharin to intact and functionally decorticate trained rats returned saccharin consumption on the next day to 62% (n equals 18) and 77% (n equals 19), respectively. Over-trained conditioned saccharin aversion was affected by forced extinction in a similar way (saccharin intake increased from 28% to 50% and 63%, respectively). Intact brain rats refused to swallow saccharin during forced feeding. while functionally decorticate animals showed no signs of aversion; but extinction was almost equal in both cases. Application of lithium chloride after forced feeding of saccharin in functionally decorticate rats neither prevented extinction of conditioned taste aversion nor reestablished the aversion habit extinguished earlier with intact brain. It is concluded that acquisition of the conditioned taste aversion requires cortical input to a short-term memory file, whereas decorticate extinction can be induced by subcortical gustatory processing analogous to the mechanism controlling feeding behavior during the preweaning period.
通过将饮用糖精与随后的氯化锂中毒联系起来，在大鼠中建立的条件性味觉厌恶使糖精摄入量降至正常消耗量的22%。对完整的和功能去皮质的受过训练的大鼠强制喂食糖精后，第二天糖精消耗量分别恢复到62%（n = 18）和77%（n = 19）。过度训练的条件性糖精厌恶以类似方式受到强制消退的影响（糖精摄入量分别从28%增加到50%和63%）。完整大脑的大鼠在强制喂食期间拒绝吞咽糖精，而功能去皮质的动物没有厌恶迹象；但在两种情况下消退情况几乎相同。在功能去皮质的大鼠中对糖精进行强制喂食后施用氯化锂，既不能阻止条件性味觉厌恶的消退，也不能重新建立先前在完整大脑时已消退的厌恶习惯。得出的结论是，条件性味觉厌恶的获得需要皮质向短期记忆文件的输入，而皮质切除后的消退可由类似于控制断奶前时期进食行为的机制的皮质下味觉处理诱导。
