Rosenson R S
Preventive Cardiology Center, Rush-Presbyterian-St. Luke's Medical Center, 1725 West Harrison Street, Suite 1159, Chicago, IL 60612, USA.
Cardiol Rev. 1999 Nov-Dec;7(6):342-8. doi: 10.1097/00045415-199911000-00012.
Several angiographic-based trials have established that triglyceride remnant particles are associated with progression of coronary stenosis, and a recent prospective study has shown that triglycerides are associated with coronary heart disease (CHD), even after adjustment for high-density lipoprotein cholesterol. The importance of plasma triglycerides in CHD risk must be interpreted within the context of other plasma lipoproteins, as well as the fasting and postprandial triglyceride levels. Recommendations for triglyceride lowering are empiric because of the lack of randomized clinical trial data that evaluate triglyceride-lowering therapies and CHD prevention. This article presents a clinical approach to the management of hypertriglyceridemia.
多项基于血管造影的试验已证实，甘油三酯残粒与冠状动脉狭窄的进展相关，并且最近一项前瞻性研究表明，即使在调整了高密度脂蛋白胆固醇之后，甘油三酯仍与冠心病（CHD）相关。血浆甘油三酯在冠心病风险中的重要性必须结合其他血浆脂蛋白以及空腹和餐后甘油三酯水平来解读。由于缺乏评估降低甘油三酯疗法与冠心病预防的随机临床试验数据，降低甘油三酯的建议是经验性的。本文介绍了一种治疗高甘油三酯血症的临床方法。
