Krasowska D, Chodorowska G, Kozioł M, Czelej D
Department of Dermatology, Medical University, Radziwillowska 13, 20-080 Lublin, Poland.
Med Sci Monit. 2000 Mar-Apr;6(2):353-5.
The aim of the study was to determine the plasma level of sICAM-1 in acute psoriatic patients in contrast to normal subjects. Moreover, we have tried to answer whether disease severity index (PASI) correlates with plasma level of sICAM-1. We have determined the plasma levels of sICAM-1 by ELISA (Genzyme Corporation) in 23 patients with acute psoriasis before and after the treatment of the disease and in 11 controls. Patients with acute psoriasis have displayed higher levels of sICAM-1 (306.4 +/- 226.8 ng/ml) compared with the controls (141.2 +/- 49.2 ng/ml) and the same patients after clearing of the disease (154.7 +/- 126.7 ng/ml). We have not found any correlation between plasma levels of sICAM-1 and severity index of psoriasis (PASI). We have concluded: the plasma levels of sICAM-1 are not related to disease severity in acute psoriasis. Clearing of the psoriasis is followed by significant fall of plasma sICAM-1.
本研究的目的是测定急性银屑病患者与正常受试者相比的可溶性细胞间黏附分子-1（sICAM-1）血浆水平。此外，我们试图回答疾病严重程度指数（PASI）是否与sICAM-1血浆水平相关。我们采用酶联免疫吸附测定法（ELISA，Genzyme公司）测定了23例急性银屑病患者在疾病治疗前后以及11名对照者的sICAM-1血浆水平。与对照组（141.2±49.2 ng/ml）以及疾病消退后的同一批患者（154.7±126.7 ng/ml）相比，急性银屑病患者的sICAM-1水平更高（306.4±226.8 ng/ml）。我们未发现sICAM-1血浆水平与银屑病严重程度指数（PASI）之间存在任何相关性。我们得出结论：急性银屑病患者的sICAM-1血浆水平与疾病严重程度无关。银屑病消退后，血浆sICAM-1显著下降。
