Tyczyńska-Hoffmann B, Szklarska-Szczepanik A, Swincow G, Adamska I, Michalska K, Łoś E, Czerwionka-Szaflarska M
Department of Paediatrics, Allergology and Gastroenterology, Medical University, ul. Ujejskiego 75, 85-168 Bydgoszcz, Poland.
Med Sci Monit. 2000 Mar-Apr;6(2):361-4.
The aim of the study was the estimation of the incidence of HCV infection and the analysis of risk factors for the infection in hospitalized children.
Retrospective analysis of the data of 1263 patients treated in hospital wards of Chair and Department of Gastroenterology and Paediatric Diseases from July 1995 to March 1998; all the patients had hepatitis C virus antibodies determined. Hepatitis C virus antibodies were assessed with the use of enzyme immunoassay. All the positive results were confirmed by means of Lia Tek HCV or PCR HCV RNA method. History data regarding frequency of previous hospitalizations, operations, blood transfusions and invasive diagnostic procedures patients had undergone were included in analysis.
HCV infection was diagnosed in 47 children which accounted for 3.7% of the group enrolled in the study. The majority, that is 96.2% of seropositive children had the history of hospitalization, while 73.2% of them underwent intervention procedures disrupting tissue continuity during previous hospitalizations. Physical examination analysis indicates that all the patients with antibodies against HCV could have acquired the infection through parenteral transmission. The data indicating another route of transmission were not obtained (e.g. familial transmission).
本研究旨在评估丙型肝炎病毒（HCV）感染的发生率，并分析住院儿童感染的危险因素。
对1995年7月至1998年3月在胃肠病学与儿科疾病教研室及科室病房接受治疗的1263例患者的数据进行回顾性分析；所有患者均检测了丙型肝炎病毒抗体。采用酶免疫测定法评估丙型肝炎病毒抗体。所有阳性结果均通过Lia Tek HCV或PCR HCV RNA方法进行确认。分析纳入了患者既往住院、手术、输血及侵入性诊断操作的频率等病史数据。
47名儿童被诊断为HCV感染，占研究纳入组的3.7%。大多数血清阳性儿童（即96.2%）有住院史，其中73.2%在既往住院期间接受过破坏组织连续性的干预操作。体格检查分析表明，所有抗HCV抗体阳性患者可能通过肠道外传播感染。未获得提示其他传播途径的数据（如家庭传播）。
