Géher P, Gömör B
Rheumatology and Physiotherapy, Semmelweis University of Medical Sciences, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary.
Med Sci Monit. 2001 Jan-Feb;7(1):105-7.
A case history of a patient with ankylosing spondylitis and peripheral arthritis unresponsive to the conventional drug therapy, but successfully controlled by the use of cyclosporin.
In a 68 years old female patient with a 36 years history of typical ankylosing spondylitis a peripheral polyarthritis (hands, feet, wrists, and knees) developed. The patient did not suffer any other disease known to cause secondary spondylitis (psoriasis, inflammatory, bowel, disease). After the unsuccessful use of non-steroidal antiinflammatory drugs a combination therapy with cyclosporin (4 mg/kg/day) and azapropazone (300 mg t.i.d.) was introduced.
Clinical improvement was achieved after 6 months of combined therapy, the polyarthritis completely resolved after one year. Therefore cyclosporin was discontinued. After one year the polyarthritis reappeared therefore the cyclosporin therapy was reinstituted with success.
Cyclosporin has proved consistently effective in our case to control the peripheral arthritis associated with ankylosing spondylitis.
一名强直性脊柱炎合并周围关节炎患者，对传统药物治疗无反应，但使用环孢素成功控制病情。
一名68岁女性患者，有36年典型强直性脊柱炎病史，出现周围多关节炎（手、足、腕和膝）。患者未患任何已知可引起继发性脊柱炎的其他疾病（银屑病、炎症性肠病）。在使用非甾体抗炎药治疗失败后，引入环孢素（4毫克/千克/天）和阿扎丙宗（300毫克，每日三次）联合治疗。
联合治疗6个月后临床症状改善，多关节炎在1年后完全缓解。因此停用环孢素。1年后多关节炎复发，因此重新使用环孢素治疗并取得成功。
在我们的病例中，环孢素已被证明能持续有效地控制与强直性脊柱炎相关的周围关节炎。
