恶臭假单胞菌F6中对羟基苯乙酸的代谢
p-Hydroxyphenylacetic Acid Metabolism in Pseudomonas putida F6.
作者信息
O'Connor K E, Witholt B, Duetz W
机构信息
Institut fur Biotechnologie, ETH Honggerberg, Zurich, Switzerland.
出版信息
J Bacteriol. 2001 Feb;183(3):928-33. doi: 10.1128/JB.183.3.928-933.2001.
Abstract
Pseudomonas putida F6 was found to metabolize p-hydroxyphenylacetic acid through 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxymandelic acid, and 3,4-dihydroxybenzaldehyde. Cell extracts of P. putida F6 catalyze the NAD(P)H-independent hydroxylation of p-hydroxyphenylacetic acid to 3,4-dihydroxyphenylacetic acid which is further oxidized to 3,4-dihydroxymandelic acid. Oxidation and decarboxylation of the latter yields 3,4-dihydroxybenzaldehyde. A red-brown color accompanies all of the above enzyme activities and is probably due to the polymerization of quinone-like compounds. 3,4-Dihydroxybenzaldehyde is further metabolized through extradiol ring cleavage.
摘要
恶臭假单胞菌F6被发现可通过3,4 - 二羟基苯乙酸、3,4 - 二羟基扁桃酸和3,4 - 二羟基苯甲醛代谢对羟基苯乙酸。恶臭假单胞菌F6的细胞提取物催化对羟基苯乙酸进行不依赖于NAD(P)H的羟基化反应生成3,4 - 二羟基苯乙酸，后者进一步氧化为3,4 - 二羟基扁桃酸。后者的氧化和脱羧反应生成3,4 - 二羟基苯甲醛。上述所有酶活性均伴有红棕色，这可能是由于醌类化合物的聚合所致。3,4 - 二羟基苯甲醛通过间位二醇环裂解进一步代谢。
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