4-羟基苯乙酸和高原儿茶酸的细菌降解作用
Bacterial degradation of 4-hydroxyphenylacetic acid and homoprotocatechuic acid.
作者信息
Sparnins V L, Chapman P J, Dagley S
出版信息
J Bacteriol. 1974 Oct;120(1):159-67. doi: 10.1128/jb.120.1.159-167.1974.
Abstract
A species of Acinetobacter and two strains of Pseudomonas putida when grown with 4-hydroxyphenylacetic acid gave cell extracts that converted 3,4-dihydroxyphenylacetic acid (homoprotocatechuic acid) into carbon dioxide, pyruvate, and succinate. The sequence of enzyme-catalyzed steps was as follows: ring-fission by a 2,3-dioxygenase, nicotinamide adenine dinucleotide-dependent dehydrogenation, decarboxylation, hydration, aldol fission, and oxidation of succinic semialdehyde. Two new metabolites, 5-carboxymethyl-2-hydroxymuconic acid and 2-hydroxyhepta-2,4-diene-1,7-dioic acid, were isolated from reaction mixtures and a third, 4-hydroxy-2-ketopimelic acid, was shown to be cleaved by extracts to give pyruvate and succinic semialdehyde. Enzymes of this metabolic pathway were present in Acinetobacter grown with 4-hydroxyphenylacetic acid but were effectively absent when 3-hydroxyphenylacetic acid or phenylacetic acid served as sources of carbon.
摘要
一种不动杆菌属细菌和两株恶臭假单胞菌在以4-羟基苯乙酸为碳源生长时，其细胞提取物可将3,4-二羟基苯乙酸（高原儿茶酸）转化为二氧化碳、丙酮酸和琥珀酸。酶促反应步骤如下：由一种2,3-双加氧酶进行环裂解、烟酰胺腺嘌呤二核苷酸依赖性脱氢、脱羧、水合、醛醇裂解以及琥珀酸半醛的氧化。从反应混合物中分离出两种新的代谢产物，5-羧甲基-2-羟基粘康酸和2-羟基庚-2,4-二烯-1,7-二酸，并且发现第三种代谢产物4-羟基-2-酮基庚二酸可被提取物裂解生成丙酮酸和琥珀酸半醛。该代谢途径的酶存在于以4-羟基苯乙酸为碳源生长的不动杆菌中，但当以3-羟基苯乙酸或苯乙酸作为碳源时则基本不存在。
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