Klages U, Markus A, Lingens F
J Bacteriol. 1981 Apr;146(1):64-8. doi: 10.1128/jb.146.1.64-68.1981.
Pseudomonas sp. strain CBS3 was able to utilize 4-chlorophenylacetic acid as the sole source of carbon and energy. When this strain was grown with 4-chlorophenylacetic acid, homoprotocatechuic acid was found to be an intermediate which was further metabolized by the meta-cleavage pathway. Furthermore, three isomers of chlorohydroxyphenylacetic acid, two of them identified as 3-chloro-4-hydroxyphenylacetic acid and 4-chloro-3-hydroxyphenylacetic acid, were isolated from the culture medium. 4-Hydroxyphenylacetic acid was catabolized in a different manner by the glutathione-dependent homogentisate pathway. Degradation enzymes of both of these pathways were inducible.
假单胞菌属菌株CBS3能够利用4-氯苯乙酸作为唯一的碳源和能源。当该菌株在4-氯苯乙酸中生长时,发现高原儿茶酸是一种中间体,它通过间位裂解途径进一步代谢。此外,从培养基中分离出了氯羟基苯乙酸的三种异构体,其中两种被鉴定为3-氯-4-羟基苯乙酸和4-氯-3-羟基苯乙酸。4-羟基苯乙酸通过谷胱甘肽依赖性尿黑酸途径以不同的方式进行分解代谢。这两种途径的降解酶都是可诱导的。