Asai M, Aragane Y, Kawada A, Shimada T, Kanamaru A, Yamada H, Tezukam T
Department of Dermatology, Kinki University School of Medicine, Osaka, Japan.
J Am Acad Dermatol. 2001 Mar;44(3):530-1. doi: 10.1067/mjd.2001.112377.
Pyoderma gangrenosum is a neutrophilic dermatosis that may be associated with myeloid malignancies. Less information is available about the association of pyoderma gangrenosum with lymphoid malignancies. We present, to our knowledge, the first case of pyoderma gangrenosum associated with biphenotypic acute leukemia wherein the malignant cells show a phenotype specific for myelogenic and lymphocytic leukemia. Histopathologic examination revealed rather nonspecific features without involvement of leukemic cells in the skin lesions. Treatment with systemic steroids was followed by characteristically rapid healing of the skin lesion.
坏疽性脓皮病是一种中性粒细胞性皮肤病，可能与髓系恶性肿瘤有关。关于坏疽性脓皮病与淋巴系恶性肿瘤的关联，目前所知较少。据我们所知，我们报告了首例与双表型急性白血病相关的坏疽性脓皮病病例，其中恶性细胞表现出髓系和淋巴细胞白血病特有的表型。组织病理学检查显示特征不明显，皮肤病变中未累及白血病细胞。全身使用类固醇治疗后，皮肤病变典型地迅速愈合。
