Kitagawa N, Ikeda M, Kodama H
Department of Dermatology, Kochi Medical School, Japan.
J Dermatol. 1996 Feb;23(2):116-9.
A 45-year-old man with the acute form of pyoderma gangrenosum is reported. He developed characteristic ulcers that rapidly followed violaceous erythema at sites of traumatic injury. The skin lesions repeatedly appeared six times within 7 years. Each time, the skin lesions were localized to sites of trauma, and no systemic symptoms nor abnormal laboratory findings were associated. Histological findings were acute superficial inflammation with neutrophilic infiltration into the dermis. Sweet's syndrome-like skin lesions were once associated, indicating that pyoderma gangrenosum and Sweet's syndrome have a close relationship. Nonsteroidal antiinflammatory drugs, potassium iodide, and minocycline were not effective. He was successfully treated with oral administration of corticosteroid. The pathergy of this patient must have been caused not only by the trauma itself but by additional factors such as epidermal components or contaminating micro-organisms, since traumatic injury did not always cause the skin lesions.
报告了一名患有急性坏疽性脓皮病的45岁男性。他在创伤部位出现特征性溃疡，这些溃疡迅速出现在紫红色红斑之后。皮肤病变在7年内反复出现6次。每次皮肤病变都局限于创伤部位，且无全身症状，实验室检查也无异常发现。组织学检查显示为急性浅表炎症，中性粒细胞浸润至真皮。曾出现过Sweet综合征样皮肤病变，提示坏疽性脓皮病与Sweet综合征关系密切。非甾体类抗炎药、碘化钾和米诺环素均无效。口服皮质类固醇成功治愈了他。该患者的同形反应肯定不仅是由创伤本身引起的，还由诸如表皮成分或污染微生物等其他因素引起，因为创伤并不总是导致皮肤病变。
