Mohan Arun V, Ramnath Venktesh R, Patalas Eva, Attar Eyal C
Department of Medicine, Cambridge Health Alliance, 1493 Cambridge Street, Cambridge, MA 02139, USA.
Cases J. 2009 Aug 4;2:8217. doi: 10.4076/1757-1626-2-8217.
Nonspecific interstitial pneumonia has been linked to numerous etiologies including, most recently, haematologic malignancy. We present a 46-year-old woman with recent-onset rheumatologic illness who developed pulmonary symptoms as the presenting feature of biphenotypic acute leukaemia. Chest radiology demonstrated bilateral infiltrates, and lung biopsy revealed nonspecific interstitial pneumonia. Corticosteroid therapy resulted in resolution of both her pulmonary and rheumatologic symptoms, and her pulmonary symptoms did not recur following treatment of her leukemia. The case highlights the importance of searching for an underlying etiology when confronted with nonspecific interstitial pneumonia.
非特异性间质性肺炎与多种病因有关，包括最近发现的血液系统恶性肿瘤。我们报告一名46岁近期患风湿性疾病的女性，她以肺部症状作为双表型急性白血病的首发特征。胸部放射学检查显示双侧浸润，肺活检显示为非特异性间质性肺炎。皮质类固醇治疗使她的肺部和风湿性症状均得到缓解，白血病治疗后她的肺部症状未复发。该病例强调了面对非特异性间质性肺炎时寻找潜在病因的重要性。
