低剂量阿司匹林不会提高接受卵胞浆内单精子注射患者的着床率：一项前瞻性随机研究。
Low-dose aspirin does not increase implantation rates in patients undergoing intracytoplasmic sperm injection: a prospective randomized study.
作者信息
Urman B, Mercan R, Alatas C, Balaban B, Isiklar A, Nuhoglu A
机构信息
Assisted Reproduction Unit, VKV American Hospital of Istanbul, Guzelbahce Sok No. 2, Nisantasi 80200, Istanbul, Turkey.
出版信息
J Assist Reprod Genet. 2000 Nov;17(10):586-90. doi: 10.1023/a:1026491426423.
Abstract
PURPOSE
The aim was to evaluate the effect of aspirin on pregnancy and implantation rates in an unselected group of patients undergoing intracytoplasmic sperm injection (ICSI).
METHODS
Two hundred and seventy-nine patients were randomized to receive 80 mg of aspirin (n = 139) or no treatment (r = 136) starting from the first day of controlled ovarian hyperstimulation.
RESULTS
Duration of stimulation, gonadotropin consumption, peak estradiol, number of oocytes retrieved, fertilization rate, cleavage rate, and number of embryos transferred were similar in the two groups. Implantation and clinical pregnancy rates were 15.6% and 39.6% versus 15.1% and 43.4% in aspirin treated and untreated groups, respectively (P > 0.05).
CONCLUSIONS
Low-dose aspirin administration does not improve implantation and pregnancy rates in an unselected group of patients undergoing ICSI.
摘要
目的
旨在评估阿司匹林对一组未经挑选的接受卵胞浆内单精子注射（ICSI）患者的妊娠率和着床率的影响。
方法
279例患者从控制性卵巢刺激的第一天开始被随机分为两组，一组接受80毫克阿司匹林治疗（n = 139），另一组不接受治疗（n = 136）。
结果
两组在刺激持续时间、促性腺激素用量、雌二醇峰值、取卵数、受精率、卵裂率和移植胚胎数方面相似。阿司匹林治疗组和未治疗组的着床率和临床妊娠率分别为15.6%和39.6%，以及15.1%和43.4%（P > 0.05）。
结论
在一组未经挑选的接受ICSI的患者中，低剂量阿司匹林给药并不能提高着床率和妊娠率。
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