Bittencourt M A, Bolognese A M
Departamento de Ortodontia, Faculdade de Odontologia, Universidade Federal de Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Braz Dent J. 2000;11(2):117-26.
This study was undertaken to examine the normal and abnormal epithelial alterations of secondary palate in rats. Control and dexamethasone-treated embryos and fetuses of Wistar rats were evaluated by macroscopic and scanning electron microscopic analysis prior to, during, and after fusion of palatal processes. Normal alterations of the surface topography included growth and disorganization of medial edge epithelial cells followed by fusion and posterior migration to both the oral and nasal aspects of the palate. No evidence of epithelial cell death or transformation was observed. Dexamethasone-treated fetuses showed epithelial cells increased in size with a large amount of desquamation, followed by deposition of a disorganized cell layer with keratin-like characteristics. This allowed no fusion of palatal processes.
本研究旨在检查大鼠继发腭的正常和异常上皮变化。通过大体和扫描电子显微镜分析，对Wistar大鼠的对照胚胎和经地塞米松处理的胚胎及胎儿在腭突融合之前、期间和之后进行评估。表面形貌的正常变化包括内侧边缘上皮细胞的生长和紊乱，随后融合并向后迁移至腭的口腔和鼻腔面。未观察到上皮细胞死亡或转化的迹象。经地塞米松处理的胎儿显示上皮细胞大小增加，伴有大量脱屑，随后沉积了一层具有角蛋白样特征的紊乱细胞层。这使得腭突无法融合。
