Wetter O, Schmidt C G, Linder K H, Leene W
J Cancer Res Clin Oncol. 1979 Jun 8;94(2):207-23. doi: 10.1007/BF00422499.
Clinical and chemical findings in 6 patients with mu-chain disease are reported. In all of these patients a lymphoproliferative disease was observed which by its symptoms resembled CLL. This similarity was underlined by the finding of an impaired response of PBL of the patients to mitogens as PHA, PWM, and Con A. A substantial result of our studies lies in the fact that the presence of mu-chains in the serum does not correlate with a clinically defined entity. Moreover, mu-chains have been observed in a case of benign lymphadenopathy. In one case a good remission of 4 years duration could be induced by the application of cytostatic agents.
报告了6例μ链病患者的临床和化学检查结果。所有这些患者均观察到一种淋巴增殖性疾病，其症状类似于慢性淋巴细胞白血病（CLL）。患者外周血淋巴细胞（PBL）对促有丝分裂原如植物血凝素（PHA）、美洲商陆有丝分裂原（PWM）和刀豆蛋白A（Con A）反应受损，这一发现进一步凸显了这种相似性。我们研究的一个重要结果是，血清中μ链的存在与临床定义的疾病实体并无关联。此外，在一例良性淋巴结病患者中也观察到了μ链。在一例患者中，应用细胞抑制剂可诱导长达4年的良好缓解。
