Artem'eva E G, Latfullin I A
Klin Med (Mosk). 2000;78(12):25-8.
Clinical effectiveness of endobronchial laser therapy (EBLT) was studied in 18-56-year-old patients with chronic bronchitis (CB) running for 2-18 years. A parallel luminescent and histochemical tests measured histamine, serotonin and catecholamines in bronchial mucosa. It was found that alveolar macrophages, lymphocytes and mucus of CB patients contain significantly higher amounts of histamine and serotonin though low amounts of catecholamines than those of healthy subjects. Levels of monoamines in alveolar macrophages, lymphocytes, neutrophils, mast and APUD cells, mucus in of CB patients correlated with the disease phase, duration, features of endobronchitis, bronchial obstruction and severity of respiratory insufficiency. EBLT produced a positive effect on CB course and bronchial mucosa bioamines. It was superior to conventional therapy in lowering of histamine and serotonin in alveolar macrophages, lymphocytes and mucus as well as in raising catecholamines.
对18至56岁、患有2至18年慢性支气管炎（CB）的患者进行了支气管内激光治疗（EBLT）的临床疗效研究。采用平行发光和组织化学检测方法测定支气管黏膜中的组胺、5-羟色胺和儿茶酚胺。结果发现，与健康受试者相比，CB患者的肺泡巨噬细胞、淋巴细胞和黏液中组胺和5-羟色胺的含量显著更高，而儿茶酚胺含量较低。CB患者的肺泡巨噬细胞、淋巴细胞、中性粒细胞、肥大细胞和APUD细胞以及黏液中的单胺水平与疾病阶段、病程、细支气管炎特征、支气管阻塞和呼吸功能不全的严重程度相关。EBLT对CB病程和支气管黏膜生物胺产生了积极影响。在降低肺泡巨噬细胞、淋巴细胞和黏液中的组胺和5-羟色胺以及提高儿茶酚胺方面，EBLT优于传统疗法。
