Buzueva I I, Shmerling M D, Filiushina E E, Markel' A L, Iakobson G S
Laboratory of Electron Microscopy and Pathophysiology, Institute of Physiology, Siberian Section of Russian Academy of Medical Sciences, Novosibirsk.
Morfologiia. 2000;118(6):61-6.
The comparative investigation of the adrenal cortex in hypertensive (INHERITED STRESS-INDUCED ARTERIAL HYPERTENSION--ISIAH) and normotensive strain (Wistar) 12-months age rats was performed. The structural signs such as the lowering of the mitochondria volume involved in steroid synthesis in showed more notable age-related reduction of steroidogenesis in the adrenal glomerular and fascicular zones and in the ISIAH rats. The lowering of the cell steroidogenesis was compensated by the adrenal glomerular and fascicular zones and hypertrophy as a result the adrenocorticocytes hyperplasia. At the same time the more considerable sclerotic changes of the adrenal cortex periendothelial space were demonstrated in the ISIAH rats. The results obtained give evidence that reducing potential of compensatory possibilities of the adrenal cortex of the ISIAH rats in the late postnatal ontogenesis period cause high probability of adaptative-compensatory mechanisms failure and pathological process aggravation in these animals.
对12月龄高血压（遗传性应激诱导性动脉高血压——ISIAH）和正常血压品系（Wistar）大鼠的肾上腺皮质进行了比较研究。所显示的参与类固醇合成的线粒体体积降低等结构迹象表明，肾上腺球状带和束状带以及ISIAH大鼠的类固醇生成与年龄相关的降低更为显著。细胞类固醇生成的降低通过肾上腺球状带和束状带的肥大得到补偿，结果是肾上腺皮质细胞增生。同时，ISIAH大鼠肾上腺皮质周内皮间隙出现了更明显的硬化改变。所获得的结果表明，在出生后晚期发育阶段，ISIAH大鼠肾上腺皮质的代偿可能性降低，导致这些动物适应性代偿机制失败和病理过程加重的可能性很高。
