Gladen B C, Zadorozhnaja T D, Chislovska N, Hryhorczuk D O, Kennicutt M C, Little R E
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Hum Exp Toxicol. 2000 Nov;19(11):597-603. doi: 10.1191/096032700671433928.
Concentrations of chrysene, benz [a] anthracene, benzo [a]-pyrene, benzo [b] fluoranthene, indeno [1,2,3-c,d] pyrene, dibenz [a,h] anthracene, and benzo [g,h,i] perylene were measured in placentas from 200 women from two cities in Ukraine, Kyiv and Dniprodzerzhinsk. The participants had no special exposures and were chosen from among subjects in an ongoing study of reproductive health. All seven of the polycyclic aromatic hydrocarbons (PAHs) were found in all placentas, with the sole exception of benzo [a] pyrene in one placenta. Chrysene was present at the highest concentrations, with median 1.38 ng/g dry weight. Dibenz [a,h] anthracene and benzo [g,h,i] perylene had the lowest concentrations; each had median 0.73 ng/g dry weight. Concentrations in Kyiv were slightly higher than those in Dniprodzerzhinsk, but the difference was significant only for dibenz [a,h] anthracene. Dibenz [a,h] anthracene and benzo [g,h,i] perylene increased significantly with maternal body mass index, but other PAHs showed no such pattern. Placentas from deliveries in autumn or winter had slightly but not significantly higher concentrations. Concentrations were not related to maternal age. There were too few smokers in the sample for meaningful evaluation. No associations were seen between any of the placental PAH concentrations and birth weight of the infant.
对来自乌克兰基辅和第聂伯罗捷尔任斯克两个城市的200名女性的胎盘进行了测定，分析了其中的屈、苯并[a]蒽、苯并[a]芘、苯并[b]荧蒽、茚并[1,2,3-c,d]芘、二苯并[a,h]蒽和苯并[g,h,i]苝的浓度。参与者无特殊暴露史，是从一项正在进行的生殖健康研究的受试者中选取的。在所有胎盘中均发现了所有七种多环芳烃（PAH），只有一个胎盘未检测到苯并[a]芘。屈的浓度最高，干重中位数为1.38 ng/g。二苯并[a,h]蒽和苯并[g,h,i]苝的浓度最低，干重中位数均为0.73 ng/g。基辅的浓度略高于第聂伯罗捷尔任斯克，但仅二苯并[a,h]蒽的差异具有统计学意义。二苯并[a,h]蒽和苯并[g,h,i]苝的浓度随产妇体重指数显著增加，但其他PAH未呈现此规律。秋季或冬季分娩的胎盘浓度略高，但差异无统计学意义。浓度与产妇年龄无关。样本中吸烟者过少，无法进行有意义的评估。未发现胎盘PAH浓度与婴儿出生体重之间存在任何关联。
