整合素拮抗剂
Integrin antagonists.
作者信息
Curley G P, Blum H, Humphries M J
机构信息
School of Biological Sciences, University of Manchester, UK.
出版信息
Cell Mol Life Sci. 1999 Oct 30;56(5-6):427-41. doi: 10.1007/s000180050443.
Integrins are a family of cell surface glycoproteins that mediate numerous cell-cell and cell-matrix interactions and are involved in biological processes such as tissue morphogenesis, leukocyte recirculation and migration, wound healing, blood clotting and immune response. Aberrant cell adhesion has been implicated in the pathogenesis of several diseases, including a number of inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and asthma, as well as cancer and coronary heart disease. As such integrins are seen as excellent targets for the development of therapeutic agents. This report begins with an examination of the structure of integrin molecules and their ligands and then goes on to review the current state of development of antiintegrin antagonists.
整合素是一类细胞表面糖蛋白，介导众多细胞间和细胞与基质间的相互作用，并参与组织形态发生、白细胞再循环与迁移、伤口愈合、血液凝固及免疫反应等生物学过程。异常的细胞黏附与多种疾病的发病机制有关，包括类风湿性关节炎、炎症性肠病和哮喘等多种炎症性疾病，以及癌症和冠心病。因此，整合素被视为开发治疗药物的理想靶点。本报告首先考察整合素分子及其配体的结构，然后综述抗整合素拮抗剂的当前开发状况。
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