线粒体外膜前体蛋白转位酶：受体与一般导入孔道
The preprotein translocase of the outer mitochondrial membrane: receptors and a general import pore.
作者信息
Meisinger C, Brix J, Model K, Pfanner N, Ryan M T
机构信息
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Germany.
出版信息
Cell Mol Life Sci. 1999 Nov 30;56(9-10):817-24. doi: 10.1007/s000180050028.
Abstract
Cytosol-synthesized preproteins destined for the mitochondria are transported across the outer membrane by the translocase of the mitochondrial outer membrane (TOM complex). This dynamic transport machinery can be divided into receptors that recognize preprotein targeting signals and components of the general import pore complex that mediate preprotein transport across the outer membrane. This review focuses on recent studies dealing with the central questions regarding the pore-forming subunits, and architecture and gating of the translocation channel of the outer membrane.
摘要
定位于线粒体的胞质溶胶合成前体蛋白通过线粒体外膜转位酶（TOM复合体）转运穿过外膜。这种动态转运机制可分为识别前体蛋白靶向信号的受体和介导前体蛋白穿过外膜的一般导入孔复合体的组分。本综述重点关注有关外膜转位通道的成孔亚基、结构和门控等核心问题的最新研究。
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