Isimi C Y, Kunle O O, Bangudu A B
Dept. of Pharmaceutical Technology and Raw Material Development, National Institute for Pharmaceutical Research and Development, P.M.B. 21, Garki, Abuja, Nigeria.
Boll Chim Farm. 2000 Sep-Oct;139(5):199-204.
The mucilage extracted from the kernels of Irvingia gabonensis was evaluated for use as suspending and emulsifying agent. The rheological behaviour of the mucilage was studied and compared to that of tragacanth. As a suspending agent, Irvingia mucilage was compared to tragacanth at various concentrations (0.5, 1.0, 1.5 and 2.0% w/v) in the formulation of sulphanilamide suspensions. At all concentrations the formulated suspensions with Irvingia mucilage gave higher Hu (final sedimentation height) and F (sedimentation volume) values. As an emulsifying agent, the properties of Irvingia mucilage was compared to tragacanth and acacia gum. The emulsions prepared with 0.6, 1.0, and 1.5% tragacanth and Irvingia 'cracked' within six days while that with 12.5% w/v acacia started showing signs of creaming at the tenth day. The emulsion prepared with 2.0% w/v Irvingia mucilage was however stable throughout the six weeks of study. The results indicate that Irvingia mucilage performed better than acacia and tragacanth even at lower concentrations in the formulation of emulsions and suspensions.
对从加蓬油桃木种子中提取的黏液进行了评估，以确定其作为悬浮剂和乳化剂的用途。研究了该黏液的流变行为，并与黄芪胶进行了比较。作为悬浮剂，在磺胺嘧啶悬浮液的配方中，将加蓬油桃木黏液与不同浓度（0.5%、1.0%、1.5%和2.0% w/v）的黄芪胶进行了比较。在所有浓度下，含有加蓬油桃木黏液的配方悬浮液具有更高的Hu（最终沉降高度）和F（沉降体积）值。作为乳化剂，将加蓬油桃木黏液的性能与黄芪胶和阿拉伯胶进行了比较。用0.6%、1.0%和1.5%的黄芪胶和加蓬油桃木制备的乳液在六天内“破裂”，而用12.5% w/v阿拉伯胶制备的乳液在第十天开始出现分层迹象。然而，用2.0% w/v加蓬油桃木黏液制备的乳液在整个六周的研究期间都保持稳定。结果表明，即使在较低浓度下，加蓬油桃木黏液在乳液和悬浮液的配方中表现也优于阿拉伯胶和黄芪胶。
