Ogaji Ikoni J, Nan Anjan, Hoag Stephen W
Department of Pharmaceutical Technology, University of Jos, Jos, Plateau State, Nigeria.
J Young Pharm. 2012 Apr;4(2):66-72. doi: 10.4103/0975-1483.96612.
The plant Irvingia gabonensis contains lipids and polymer extractives that can be a good source of excipients for oral pharmaceutical formulations. These constituents are usually extracted from the seeds with the aid of either organic solvents or enzymes. The purpose of this paper was to describe a novel, simpler, cheaper, and safer method for the simultaneous extraction of lipids and gum from I. gabonensis. A 100.0 g of seeds of I. gabonensis in 200 mL deionized water was heated at 78°C in the presence of 2.0 g sodium chloride for 1 h, and the mixture was allowed to stand for the lipids to be separated and removed by filtration. The samples were air dried at 25-30°C. The liquid fraction was centrifuged at 3445 rpm for 30 min, and the supernatant portion containing the gum was freeze dried. The samples were investigated for their true, bulk, and tapped densities as well as particle size and particle size distributions. The rheological, and near infrared absorption spectra as well as thermal behavior of the samples were also studied. The lipid and the polymeric components of I. gabonensis seeds were successfully extracted simultaneously. The true densities of the fatty and gum components were, respectively, 1.000 and 1.544 g/cm(3). The melting point of the fat was 40°C and T(g) of the gum was 232°C. These values were similar to those described in the literature for the components using the traditional method, demonstrating the effectiveness and efficiency of this simple novel method.
加蓬欧文氏果植物含有脂质和聚合物提取物，可为口服药物制剂提供良好的辅料来源。这些成分通常借助有机溶剂或酶从种子中提取。本文的目的是描述一种新颖、更简单、更便宜且更安全的方法，用于同时从加蓬欧文氏果中提取脂质和树胶。将100.0克加蓬欧文氏果种子置于200毫升去离子水中，在2.0克氯化钠存在下于78°C加热1小时，然后让混合物静置，使脂质分离并通过过滤去除。样品在25 - 30°C下风干。将液体部分以3445转/分钟的转速离心30分钟，含有树胶的上清液部分进行冷冻干燥。对样品的真密度、堆积密度和振实密度以及粒度和粒度分布进行了研究。还研究了样品的流变学、近红外吸收光谱以及热行为。成功同时提取了加蓬欧文氏果种子的脂质和聚合物成分。脂肪和树胶成分的真密度分别为1.000和1.544克/立方厘米。脂肪的熔点为40°C，树胶的玻璃化转变温度为232°C。这些值与文献中使用传统方法描述的成分值相似，证明了这种简单新颖方法的有效性和效率。
