Cabarcos Ortiz de Barrón A, Barrio Gómez E, Lado Lado F L, Rodríguez López I, Lorenzo Zúñiga V
Servicio de Medicina Interna, Unidad de Sida, Complejo Hospitalario Universitario de Santiago, Departamento de Medicina, Santiago de Compostela.
An Med Interna. 2000 Dec;17(12):632-6.
The aim of this work was to assess cellular immunity using the multitest CMI and relate its results with lymphocyte CD4 counts, and the risk to developed active tuberculosis if the multi-test's tuberculosis pápula was positive.
Prospective longitudinal follow-up of 342 IDU patients, 210 infected with HIV-1 and seronegative 132 patients. The cohort study was 165 IDU HIV-1 positive patients (128 men, 37 female). Ages was 18 to 45 years. Study time were 25 months (8-25). Tuberculin skin tests and multitest IMC were performed at baseline and each three months, and screening from active tuberculosis were performed all study when necessary was considered.
Actived tuberculosis developed in 9.25 cases per one hundred persons and year from follow-up in the ranges with better immunologic status (Score from PHR > 10 mm). There are an significative correlation between tuberculosis skin test diameter and PHR tuberculin fraction papula.
PHR performed with Multitest IMC is an useful test to evaluate cellular immune system, and HIV-1 positive patients with energy in this test or positive tuberculine fraction must be considered to isoniazid (9 months) prophylaxis.
本研究旨在使用多测试细胞介导免疫（CMI）评估细胞免疫，并将其结果与淋巴细胞CD4计数相关联，以及探讨多测试结核丘疹呈阳性时发生活动性结核病的风险。
对342名注射毒品使用者进行前瞻性纵向随访，其中210名感染HIV-1，132名血清阴性。队列研究包括165名HIV-1阳性的注射毒品使用者（128名男性，37名女性）。年龄在18至45岁之间。研究时间为25个月（8至25个月）。在基线时和每三个月进行结核菌素皮肤试验和多测试免疫细胞化学（IMC），并在必要时在整个研究期间进行活动性结核病筛查。
在免疫状态较好（PHR评分>10mm）的随访范围内，每100人年有9.25例发生活动性结核病。结核菌素皮肤试验直径与PHR结核菌素部分丘疹之间存在显著相关性。
使用多测试IMC进行的PHR是评估细胞免疫系统的有用测试，对于在该测试中表现不佳或结核菌素部分呈阳性的HIV-1阳性患者，必须考虑进行9个月的异烟肼预防。
