DeVault K R
Mayo Clinic, Jacksonville, FL 32224, USA.
Semin Gastrointest Dis. 2001 Jan;12(1):46-51.
Gastroesophageal reflux disease (GERD) can present with both typical symptoms such as heartburn and regurgitation as well as atypical symptoms. These symptoms may include chest pain, asthma, chronic cough, hoarseness, otitis media, atypical loss of dental enamel, idiopathic pulmonary fibrosis, recurrent pneumonia, chronic bronchitis and even sudden infant death. The diagnosis of GERD in these patients can often present a challenge and usually requires a combination of selected testing and therapeutic trials. Acid suppression by using proton pump inhibitors remains the treatment of choice in GERD, but some patients will also respond well to antireflux surgery. This article addresses the presentations, diagnostic challenges, and therapeutic opportunities in GERD patients with atypical presentations.
胃食管反流病（GERD）可表现为烧心和反流等典型症状以及非典型症状。这些症状可能包括胸痛、哮喘、慢性咳嗽、声音嘶哑、中耳炎、牙釉质非典型性缺失、特发性肺纤维化、反复肺炎、慢性支气管炎，甚至婴儿猝死。对这些患者进行GERD诊断往往具有挑战性，通常需要综合运用特定检测和治疗试验。使用质子泵抑制剂抑制胃酸仍然是GERD的首选治疗方法，但一些患者对抗反流手术也会有良好反应。本文探讨了有非典型表现的GERD患者的临床表现、诊断挑战及治疗机会。
