Snyder P S, Sadek D, Jones G L
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
J Vet Intern Med. 2001 Jan-Feb;15(1):52-6. doi: 10.1892/0891-6640(2001)015<0052:eoaoev>2.3.co;2.
Left ventricular hypertrophy signals a poor prognosis in hypertensive humans. Cardiac disease is common in cats with systemic hypertension. The aims of this study were to characterize the echocardiographic findings of cats with systemic hypertension and to determine if reducing the degree of hypertension is associated with resolution of cardiac hypertrophy. Echocardiographic examinations were performed on 19 cats with naturally occurring systemic hypertension. Fourteen of these cats were subsequently studied after a minimum of 3 months of treatment with the antihypertensive agent amlodipine. Hypertensive cats had a significantly thicker interventricular septum in both systole and diastole, thicker left ventricular free wall in both systole and diastole, and larger left atrium compared to the published normal values and 74% (14/19) of the cats met criteria for left ventricular hypertrophy (diastolic septal or free-wall thickness > 0.60 cm). Systolic blood pressure was lower after treatment (217 +/- 25 mm Hg, range: 180-275 mm Hg; and 142 +/- 27 mm Hg, range: 90-200 mm Hg). No difference was found in any of the echocardiographic measurements between the untreated and treated cats, although more cats had ventricular hypertrophy before treatment (11/14) than after initiating amlodipine (6/14; P = .006). Ventricular hypertrophy is common in hypertensive cats and may resolve after the initiation of amlodipine.
左心室肥厚预示着高血压患者预后不良。心脏病在患有系统性高血压的猫中很常见。本研究的目的是描述患有系统性高血压的猫的超声心动图检查结果，并确定降低高血压程度是否与心脏肥厚的消退有关。对19只患有自然发生的系统性高血压的猫进行了超声心动图检查。其中14只猫在使用抗高血压药物氨氯地平治疗至少3个月后进行了后续研究。与已公布的正常值相比，高血压猫在收缩期和舒张期的室间隔明显增厚，在收缩期和舒张期的左心室游离壁增厚，左心房增大，并且74%（14/19）的猫符合左心室肥厚标准（舒张期室间隔或游离壁厚度>0.60 cm）。治疗后收缩压降低（217±25 mmHg，范围：180 - 275 mmHg；以及142±27 mmHg，范围：90 - 200 mmHg）。在未治疗和治疗的猫之间，任何超声心动图测量值均未发现差异，尽管治疗前有更多猫存在心室肥厚（11/14），而在开始使用氨氯地平后（6/14；P = 0.006）。心室肥厚在高血压猫中很常见，并且在开始使用氨氯地平后可能会消退。
