Animal Emergency Medical Center, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Faculty of Veterinary Medicine, Okayama University of Science, Ehime, Japan.
J Vet Med Sci. 2024 May 25;86(5):533-541. doi: 10.1292/jvms.23-0444. Epub 2024 Apr 2.
An increase in systemic blood pressure causes bleeding and ischemia owing to peripheral vascular breakdown, leading to various forms of organ damage. The brain, eyes, kidneys, and cardiovascular system are known target organs for hypertension. To our knowledge, no reports in Japan describe, in detail, the types of antihypertensive drugs used to treat hypertension in cats or its underlying causes. Therefore, we aimed to investigate the use of antihypertensive drugs in domestic cats with hypertension in Japan, the causes of hypertension, and the vital prognosis of these patients. In the present survey, we found that amlodipine was used alone (60/80 cats) or concomitantly (20/80 cats) in all cat patients with hypertension in Japan. We also determined that blood pressure measurements were not yet routinely performed on cats at veterinary clinics in Japan. Furthermore, we have new information suggesting that amlodipine administration in cats with hypertension, which lowers systolic arterial pressure levels to within the normal range (<140 mmHg), may have a negative impact on their survival. Routine blood pressure measurements for cats during their regular health checkups can help identify hypertension, and proper interpretation of blood pressure readings can facilitate suitable treatment measures.
血压升高会导致外周血管破裂出血和缺血，从而导致各种形式的器官损伤。大脑、眼睛、肾脏和心血管系统是高血压的已知靶器官。据我们所知，在日本没有详细描述用于治疗猫高血压的降压药物类型或其潜在原因的报告。因此，我们旨在调查日本患有高血压的家猫中降压药物的使用情况、高血压的病因以及这些患者的预后。在本研究中，我们发现，在日本所有患有高血压的猫患者中，氨氯地平单独使用（60/80 只猫）或联合使用（20/80 只猫）。我们还确定，在日本的兽医诊所，尚未对猫进行常规血压测量。此外，我们有新的信息表明，在患有高血压的猫中使用氨氯地平（将收缩压水平降低至正常范围内[<140mmHg]）可能会对其生存产生负面影响。在常规健康检查期间对猫进行常规血压测量有助于识别高血压，并且对血压读数的正确解释有助于采取适当的治疗措施。
