Henik R A, Snyder P S, Volk L M
Department of Medical Sciences, University of Wisconsin-Madison 53706, USA.
J Am Anim Hosp Assoc. 1997 May-Jun;33(3):226-34. doi: 10.5326/15473317-33-3-226.
Amlodipine besylate, a calcium channel blocker, was used to treat (mean +/- standard deviation [SD], 127 +/- 68 days) 12 cats with systemic hypertension. Amlodipine was administered orally at a dosage of 0.625 mg per cat (range, 0.08 to 0.23 mg/kg body weight; mean dose +/- SD, 0.17 +/- 0.04 mg/kg body weight) once daily as a single agent. Average indirect systolic blood pressure measurements in the 12 cases decreased significantly from 198 to 155 mmHg during amlodipine treatment. Significant changes in body weight and serum creatinine and potassium concentrations were not detected. Amlodipine appears to be a safe and effective oral treatment for systemic hypertension in cats when used chronically once daily as a single agent.
苯磺酸氨氯地平，一种钙通道阻滞剂，被用于治疗12只患有全身性高血压的猫（平均±标准差[SD]，127±68天）。氨氯地平以每只猫0.625毫克的剂量口服给药（范围为0.08至0.23毫克/千克体重；平均剂量±SD，0.17±0.04毫克/千克体重），每日一次，作为单一药物。在这12例病例中，氨氯地平治疗期间平均间接收缩压测量值从198毫米汞柱显著降至155毫米汞柱。未检测到体重、血清肌酐和钾浓度的显著变化。当每日一次长期作为单一药物使用时，氨氯地平似乎是治疗猫全身性高血压的一种安全有效的口服药物。
