Op de Coul E L, Prins M, Cornelissen M, van der Schoot A, Boufassa F, Brettle R P, Hernández-Aguado L, Schiffer V, McMenamin J, Rezza G, Robertson R, Zangerle R, Goudsmit J, Coutinho R A, Lukashov V V
Division of Public Health and Environment, Municipal Health Service, Amsterdam, The Netherlands.
AIDS. 2001 Jan 26;15(2):257-66. doi: 10.1097/00002030-200101260-00017.
To reconstruct the epidemiological relationships of the HIV epidemics among injecting drug users (IDU) in western Europe.
HIV env V3 sequences of and epidemiological data were obtained from 145 IDU who seroconverted in three sequential periods: 1984-1988, 1989-1992 and 1993-1997. The sequences were phylogenetically analysed and examined for signature patterns characteristic of northern European IDU, including the conserved GGC codon in the V3 loop.
Subpopulations of genetically related HIV strains were observed in Italy, France, Scotland and Spain, in contrast to the Netherlands, Austria and Switzerland. This difference between the two groups of countries suggests that the HIV epidemics amongst IDU in the latter group was caused by multiple virus introductions. In Edinburgh and the surrounding area, most IDU were infected with the same GGC strain over the 12-year study period. The epidemic among IDU in north-western Europe started with GGC viruses, whereas in south-western Europe non-GGC viruses predominated. This geographical separation has faded during the course of the epidemic, most likely because of virus exchange among IDU populations.
重建西欧注射吸毒者（IDU）中HIV流行的流行病学关系。
从145名在三个连续时期（1984 - 1988年、1989 - 1992年和1993 - 1997年）血清转化的IDU中获取HIV env V3序列和流行病学数据。对这些序列进行系统发育分析，并检查北欧IDU特有的特征模式，包括V3环中保守的GGC密码子。
在意大利、法国、苏格兰和西班牙观察到了基因相关的HIV毒株亚群，而荷兰、奥地利和瑞士则不同。两组国家之间的这种差异表明，后一组国家中IDU的HIV流行是由多种病毒引入引起的。在爱丁堡及其周边地区，在为期12年的研究期间，大多数IDU感染的是同一GGC毒株。欧洲西北部IDU中的流行始于GGC病毒，而在欧洲西南部，非GGC病毒占主导。这种地理分隔在流行过程中已经减弱，很可能是由于IDU群体之间的病毒交换。
