Caplinskas Saulius, Loukachov Vladimir V, Gasich Elena L, Gilyazova Alla V, Caplinskiene Irma, Lukashov Vladimir V
Centre for Communicable Diseases and AIDS and Faculty of Social Policy, University of Mykolas Romeris, Vilnius, Lithuania.
AIDS Res Hum Retroviruses. 2013 Apr;29(4):732-7. doi: 10.1089/AID.2012.0312. Epub 2013 Feb 1.
To analyze HIV-1 genotypes in Lithuania and the transmission of drug-resistant viruses, HIV-1 sequences were obtained from 138 individuals, who were diagnosed as HIV-1 infected in 1990-2008 and represented all major risk groups. Subtype A strains, dominating in the former Soviet Union (90% of cases), were found in 60% of individuals, followed by subtype B (22%) and CRF03_AB (12%) strains. The remaining 7% of the strains included variants belonging to subtype C, CRF01_AE, CRF02_AG, more complex recombinant forms, and strains that could not be reliably genotyped. Analysis of virus genotypes per risk group revealed the circulation of distinct HIV-1 strains in different risk groups: subtype A viruses were present in 82% of injecting drug users (IDUs), but less than a half of heterosexually infected individuals and cases with unknown transmission route, and none of men having sex with men (MSM). We observed no mutations causing drug resistance among 27 newly diagnosed HIV-1 cases.
为分析立陶宛的HIV-1基因型及耐药病毒的传播情况，从138名个体中获取了HIV-1序列，这些个体于1990年至2008年被诊断为HIV-1感染，代表了所有主要风险群体。在前苏联占主导地位的A型毒株（90%的病例）在60%的个体中被发现，其次是B型毒株（22%）和CRF03_AB毒株（12%）。其余7%的毒株包括属于C型、CRF01_AE型、CRF02_AG型的变体、更复杂的重组形式以及无法可靠进行基因分型的毒株。按风险群体对病毒基因型进行分析发现，不同风险群体中存在不同的HIV-1毒株传播情况：82%的注射吸毒者（IDU）中存在A型病毒，但异性感染个体和传播途径不明的病例中该比例不到一半，男男性行为者（MSM）中则未发现。在27例新诊断的HIV-1病例中，我们未观察到引起耐药的突变。
