Reddy M S, Suneetha N, Thomas R K, Battu R R
Dept. of Ophthalmology, St. John's Medical College and Hospital, Sarjapur Road, Bangalore-560 034, India.
Indian J Ophthalmol. 2000 Sep;48(3):223-6.
To study the effect of a topical non-steroidal anti-inflammatory drug as an alternative to topical steroids for postoperative control of inflammation in cataract surgery.
The effect of diclofenac sodium 0.1% following cataract surgery was studied and compared to routine corticosteroid, dexamethasone phosphate 1% in a prospective, double-blind randomized study. Both groups were similar in baseline parameters. Postoperative inflammatory response, intraocular pressure and best-corrected visual acuity following standard extracapsular cataract extraction were assessed in both groups in the initial 21 days and the severity of these parameters was graded. The severity of postoperative inflammatory response to the two drugs was graded at 1, 3, 7, 14 and 21 days. Intraocular pressure and visual acuity at baseline and endpoint were compared and statistically analyzed.
The two groups did not differ statistically in treatment effect for any of the variables including aqueous cells, flare, ciliary congestion, Descemet's folds, visual acuity and intraocular pressure (p < 0.001). However there seemed to be a trend towards quicker improvement with corticosteroid when cells in the anterior chamber were considered. There were no side effects from topical diclofenac, and it was well tolerated.
Diclofenac sodium is as effective as topical corticosteroid and can be used as an alternative in routine postoperative treatment following uncomplicated cataract surgery.
研究局部使用非甾体抗炎药作为局部使用类固醇的替代药物，用于白内障手术后炎症控制的效果。
在一项前瞻性、双盲随机研究中，研究了0.1%双氯芬酸钠在白内障手术后的效果，并与常规皮质类固醇1%磷酸地塞米松进行了比较。两组在基线参数方面相似。在最初的21天内，对两组患者在标准囊外白内障摘除术后的炎症反应、眼压和最佳矫正视力进行评估，并对这些参数的严重程度进行分级。在第1、3、7、14和21天对两种药物术后炎症反应的严重程度进行分级。比较并统计分析基线和终点时的眼压和视力。
两组在包括房水细胞、闪光、睫状充血、Descemet褶皱、视力和眼压等任何变量的治疗效果上均无统计学差异（p < 0.001）。然而，当考虑前房内的细胞时，皮质类固醇似乎有更快改善的趋势。局部使用双氯芬酸没有副作用，耐受性良好。
双氯芬酸钠与局部皮质类固醇一样有效，可作为单纯性白内障手术后常规术后治疗的替代药物。
