急性中耳炎的治疗：参与临床试验的儿童具有代表性吗？
Treatment of acute otitis media: are children entered into clinical trials representative?
作者信息
Bain J
机构信息
Tayside Centre for General Practice, University of Dundee, Kirsty Semple Way, Dundee DD2 4AD.
出版信息
Br J Gen Pract. 2001 Feb;51(463):132-3.
This study involved a meta-analysis of randomised control studies of the treatment of acute otitis media and judged the characteristics of these trials on the basis of methods, age groups, interventions, and outcomes. An investigation of the eight trials reported in the meta-analysis of clinical trials revealed that the number of children entered per doctor in all practices was low and that the recruitment rate was probably lower than 44%. Low recruitment rates indicate that the type of children entered into trials may only relate to those with mild to moderate symptoms and signs, which could explain why the results of these trials show that antibiotics are not essential in treating acute otitis media.
本研究对急性中耳炎治疗的随机对照研究进行了荟萃分析，并根据方法、年龄组、干预措施和结果来判断这些试验的特征。对临床试验荟萃分析中报告的八项试验进行调查发现，所有医疗机构中每位医生纳入的儿童数量较少，且招募率可能低于44%。低招募率表明，纳入试验的儿童类型可能仅与那些有轻至中度症状和体征的儿童有关，这可以解释为什么这些试验的结果表明抗生素在治疗急性中耳炎时并非必不可少。
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