Wise G N
Am J Ophthalmol. 1975 Mar;79(3):349-7. doi: 10.1016/0002-9394(75)90605-4.
Of 150 consecutive cases of preretinal macular fibrosis that occurred predominantly in older subjects, 118 cases involved only one eye while 32 occurred binocularly. The ratio of women to men was 3:2. Visual acuity was usually 20/50 or better, and only four of 178 eyes had acuity below 20/200. The vast majority of lesions involved the macula and few extended outside the macular zone. The characteristic clinical finding on ophthalmoscopy was a glinting reflex probably due to a layer of connective tissue cells lying on the internal limiting membrane. Small white exudates, venous abnormalities, and occasional hemorrhages may also be part of prepretinal macular fibrosis. Amsler grid testing usually demonstrated irregularity and distortion of some part of the grid. Fluorescein angiography revealed a characteristic tortuosity of the small macular vessels. Most eyes had previous posterior vitreous detachments but, except for one possible case, there were no cases where the posterior vitreous body was adherent to either the retinal membrane or the macular region. There was no significant systemic disease related to preretinal macular fibrosis. In most instances, preretinal macular fibrosis either was stationary or slowly progressive. The etiology and treatment of the condition remains obscure.
在150例主要发生于老年患者的视网膜前黄斑纤维化连续病例中，118例仅累及单眼，32例双眼发病。女性与男性的比例为3:2。视力通常为20/50或更好，178只眼中只有4只眼的视力低于20/200。绝大多数病变累及黄斑，很少扩展到黄斑区以外。眼底检查的特征性临床发现是一种闪烁反射，可能是由于一层结缔组织细胞位于内界膜上。小的白色渗出物、静脉异常和偶尔的出血也可能是视网膜前黄斑纤维化的一部分。Amsler方格表检查通常显示方格的某些部分不规则和变形。荧光素血管造影显示黄斑小血管有特征性的迂曲。大多数眼睛既往有玻璃体后脱离，但除1例可能病例外，没有玻璃体后皮质附着于视网膜膜或黄斑区的病例。没有与视网膜前黄斑纤维化相关的明显全身性疾病。在大多数情况下，视网膜前黄斑纤维化要么静止，要么缓慢进展。该病的病因和治疗仍不清楚。
