Hahn H
Institute of Pathology, Technical University Munich/GSF-Research Center for Environment and Health, Neuherberg, Germany.
IARC Sci Publ. 2001;154:93-100.
Development of skin cancer is a result of interactions between genetic and environmental factors. Exposure to sunlight is an established cause of non-melanoma skin cancer as well as of melanoma. Other additional factors such as exposure to environmental chemicals (e.g., chimney soot, arsenic compounds), chronic irritation of the skin, viral infections and the immune status of the host may predispose to skin cancer. The high incidence of skin cancer highlights the need for development of more effective chemopreventive agents. This requires a better understanding of genetically determined host susceptibility, which is increasingly acknowledged as a major factor in the causation of skin tumours.
皮肤癌的发生是遗传因素和环境因素相互作用的结果。阳光照射是已确定的非黑色素瘤皮肤癌以及黑色素瘤的病因。其他额外因素，如接触环境化学物质（如烟囱烟灰、砷化合物）、皮肤的慢性刺激、病毒感染和宿主的免疫状态，可能会使人易患皮肤癌。皮肤癌的高发病率凸显了开发更有效化学预防剂的必要性。这需要更好地了解由基因决定的宿主易感性，而宿主易感性日益被认为是皮肤肿瘤发生的一个主要因素。
