生殖器硬化性苔藓与黑色素瘤；一项系统综述。
Genital lichen sclerosus and melanoma; a systematic review.
作者信息
Sim Sharmaine J Y, Dear Katherine, Mastoraki Evanthia, James Mariel, Haider Aiman, Ellery Peter, Freeman Alex, Alnajjar Hussain M, Muneer Asif, Watchorn Richard, Kravvas Georgios, Bunker Christopher B
机构信息
University College London Medical School London UK.
Department of Dermatology University College London Hospitals NHS Foundation Trust London UK.
出版信息
Skin Health Dis. 2022 Dec 11;3(2):e198. doi: 10.1002/ski2.198. eCollection 2023 Apr.
BACKGROUND
Lichen sclerosus (LSc) is a chronic, inflammatory, destructive skin disease with a predilection for the genitalia (GLSc). An association with vulval (Vu) and penile (Pe) squamous carcinoma (SCC) is now well established but melanoma (MM) has only rarely been reported complicating GLSc.
METHODS
We have performed a systematic literature review of GLSc in patients with genital melanoma (GMM). Only articles that mentioned both GMM and LSc affecting either the penis or vulva were included.
RESULTS
Twelve studies with a total of 20 patients were included. Our review shows that an association of GLSc with GMM has been more frequently reported in women and female children than men viz, 17 cases compared with three. It is notable that five of the cases (27.8%) concerned female children aged under twelve.
DISCUSSION
These data suggest a rare association between GLSc and GMM. If proven, there arise intriguing questions about pathogenesis and consequences for counselling of patients and follow-up.
背景
硬化性苔藓（LSc）是一种慢性、炎症性、破坏性皮肤病，好发于生殖器部位（GLSc）。现已明确其与外阴（Vu）和阴茎（Pe）鳞状细胞癌（SCC）有关，但仅有罕见报道称黑色素瘤（MM）并发于GLSc。
方法
我们对患有生殖器黑色素瘤（GMM）的患者的GLSc进行了系统的文献综述。仅纳入提及GMM和LSc同时累及阴茎或外阴的文章。
结果
共纳入12项研究，涉及20例患者。我们的综述表明，GLSc与GMM的关联在女性和女童中比男性更常被报道，即17例对比3例。值得注意的是，其中5例（27.8%）为12岁以下的女童。
讨论
这些数据表明GLSc与GMM之间存在罕见关联。如果得到证实，将引发关于发病机制以及对患者咨询和随访的影响等有趣问题。
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