[Safety and clinical efficiency of long-term complete blockade of renin-angiotensin-aldosterone system in patients with chronic obstructive pulmonary diseases].

AIM

To study a corrective influence of a complete blockade of renin-angiotensin-aldosterone system (RAAS) on right ventricular failure in patients with chronic obstructive pulmonary diseases (COPD).

MATERIAL AND METHODS

91 COPD patients were randomised into 3 groups who received standard therapy (ST), ST + losartan, ST + losartan + aldactone. The duration of the follow-up was 24 months.

RESULTS

A complete RAAS blockade produced a significant decline in the pressure in the pulmonary artery, improved diastolic and systolic right ventricular function. This led to decreased number of hospitalizations because of progressing right ventricular failure.

CONCLUSION

Safety of therapy with ACE inhibitor and aldactone was proved by a comparison of the number of side effects in the three groups.