Iskenderov B G, Latyshev D S
Klin Med (Mosk). 2000;78(10):37-40.
Cardiohemodynamic effects of obsidan, nifedipin, captopril and prasosine were compared when the drugs were given in a 4-week course regarding circulation type and stimulation regime to 74 patients with artificial pacemaker suffering from mild or moderate essential hypertension. A peculiar action of obsidan, nifedipin and prasosine in cardiac pacing found at echocardiography is explained by the absence of frequency-dependent (chronotropic) cardiohemodynamic effects. Obsidan lowered blood pressure most effectively in hyperkinetic circulation. Nifedipine, captopril and prasosine were more potent in eu- and hypokinetic circulation. Reduction of arterial pressure by the above peripheral vasodilators in patients with hyperkinetic circulation results from a fall of total peripheral vascular resistance initially elevated by 16.5%, on the average. In isolated ventricular stimulation (regime VVI) vs atrial one (AAI regime) hypotensive action of the above drugs was more potent, but side effects were more frequent.
在为期4周的疗程中，针对74例患有轻度或中度原发性高血压的人工起搏器患者，比较了奥昔坦、硝苯地平、卡托普利和哌唑嗪在不同循环类型和刺激方案下的心脏血液动力学效应。在超声心动图检查中发现，奥昔坦、硝苯地平及哌唑嗪在心脏起搏方面具有独特作用，这可通过其不存在频率依赖性（变时性）心脏血液动力学效应来解释。奥昔坦在高动力循环中降压效果最为显著。硝苯地平、卡托普利和哌唑嗪在正常动力和低动力循环中效果更佳。上述外周血管扩张剂使高动力循环患者的动脉压降低，这是由于平均升高了16.5%的总外周血管阻力下降所致。在心室单腔起搏（VVI模式）与心房单腔起搏（AAI模式）相比时，上述药物的降压作用更强，但副作用更频繁。
