Iskenderov B G, Tatarchenko I P
Eksp Klin Farmakol. 1996 Jul-Aug;59(4):21-4.
The effect of a single administration and a 2-week course of obsidan treatment on cardiohemodynamics was studied in patients with an artificial cardiac pacemaker and a fixed rate of electrocardiostimulation. Echocardiography showed that obsidan reduced heart contractility and pump function in patients with an artificial cardiac pacemaker and different types of blood circulation (hyper-, eu-, and hypokinetic). The cardiohemodynamic effects of obsidan were found to be dependent on the initial type of circulation and the features of intracardiac hemodynamics in different modes of cardiac pacing.
在植入人工心脏起搏器且采用固定频率心脏电刺激的患者中，研究了单次给药及为期2周的奥西丹治疗对心脏血液动力学的影响。超声心动图显示，奥西丹可降低植入人工心脏起搏器且存在不同类型血液循环（高动力型、正常动力型和低动力型）患者的心脏收缩力及泵功能。发现奥西丹的心脏血液动力学效应取决于初始循环类型以及不同心脏起搏模式下的心内血液动力学特征。
