Mirone V, Palmieri A, Granata A M, Piscopo A, Verze P, Ranavolo R
Clinica Urologica, Università degli Studi Federico II, Napoli.
Arch Ital Urol Androl. 2000 Dec;72(4):384-7.
The aim of the study was to check the efficiency of shock waves in the treatment of Peyronie's disease. The instrument, because of its lithotriptic power, already used in the treatment of orthopedic disease and salivary stones, can be used to break plaques in induratio penis plastica. A total of 481 patients affected with Peyronie's disease were entered into a prospective trial. Patients with big plaques or with an initial stage of degeneration were excluded. We divided the patients into three treatment groups: a) shock waves alone in 56 patients; b) a combination of shock waves and calcioantagonist (perilesional injection) in 324 patients; c) calcioantagonist alone in 101 patients. The group of 101 patients (group C) treated during the previous 2 years with a medical therapy based only on the injection of calcioantagonist, was used as a control group. Ultrasound evaluation of the treated plaques showed a reduction of size in 27/56 patients of the group A, in 159/324 patients of the group B and in 39/101 patients of group C. Painful erection improved in the 91.5% of group B, against the 45.7% of group C. Furthermore, we pointed out, with interviews to the patients, a considerable improvement of the pain and of the sexual performances. The therapeutic association of shock waves with calcioantagonist injections is an effective non-operative treatment for the stabilization of Peyronie's disease.
本研究的目的是检验冲击波治疗佩罗尼氏病的疗效。该仪器因其碎石能力，已用于治疗骨科疾病和唾液腺结石，可用于击碎阴茎硬结症中的斑块。共有481例佩罗尼氏病患者进入前瞻性试验。排除有大斑块或处于退变初期的患者。我们将患者分为三个治疗组：a）56例仅接受冲击波治疗；b）324例接受冲击波与钙拮抗剂联合治疗（病灶周围注射）；c）101例仅接受钙拮抗剂治疗。将前两年仅接受钙拮抗剂注射药物治疗的101例患者（C组）作为对照组。对治疗后的斑块进行超声评估，结果显示，A组56例患者中有27例斑块尺寸减小，B组324例患者中有159例，C组101例患者中有39例。B组91.5%的患者阴茎勃起疼痛情况改善，而C组为45.7%。此外，通过对患者的访谈，我们指出疼痛和性功能有了显著改善。冲击波与钙拮抗剂注射联合治疗是稳定佩罗尼氏病的一种有效的非手术治疗方法。
