Brown M M, Brown G C, Sharma S, Kistler J, Brown H
Center for Evidence-Based Health Care Economics, Flourtown, PA 19031, USA.
Br J Ophthalmol. 2001 Mar;85(3):327-31. doi: 10.1136/bjo.85.3.327.
To ascertain utility values associated with varying degrees of legal blindness.
A cross sectional study on three group of patients. There were: (1) 15 patients with complete absence of vision (no light perception) in at least one eye who were asked to assume a scenario of no light perception in the second eye as well, (2) 17 patients with light perception to counting fingers in the better seeing eye, and (3) 33 patients with 20/200-20/400 vision in the better seeing eye. Utility values were measured using the time trade-off and standard gamble methods in each of the three groups.
The mean time trade-off utility value for the no light perception group with the theoretical scenario of bilateral absence of light perception was 0.26 (95% CI, 0.19-0.33). The mean utility value for the light perception to counting fingers group was 0.47 (95% CI, 0.33-0.61), and the mean utility value for the 20/200-20/400 group was 0.65 (95% CI, 0.58-0.72). Thus, patients with no light perception in one eye, who were presented with the same scenario in the second eye as well, were willing to trade almost 3 out of every 4 years of remaining life in return for perfect vision in each eye. Those with light perception to counting fingers would trade approximately 1 of 2 remaining years and those with 20/200-20/400 would trade approximately 1 of 3 remaining years.
There is a wide range of utility values associated with legal blindness. The utility value decreases dramatically with perceived total loss of vision (absence of light perception in each eye), compared with counting fingers to light perception vision, indicating that the preservation of even small amounts of vision in patients with legal blindness is critically important to their wellbeing and functioning in life.
确定与不同程度法定盲相关的效用值。
对三组患者进行横断面研究。三组分别为:(1)15例至少一只眼睛完全失明(无光感)的患者,要求他们设想另一只眼睛也无光感的情景;(2)17例较好眼有光感至能数指的患者;(3)33例较好眼视力为20/200 - 20/400的患者。在三组患者中分别使用时间权衡法和标准博弈法测量效用值。
在双眼均无光感这一理论情景下,无光感组的平均时间权衡效用值为0.26(95%可信区间,0.19 - 0.33)。有光感至能数指组的平均效用值为0.47(95%可信区间,0.33 - 0.61),20/200 - 20/400组的平均效用值为0.65(95%可信区间,0.58 - 0.7)。因此,一只眼睛无光感且设想另一只眼睛也如此的患者,愿意用剩余生命中近四分之三的时间来换取双眼的完美视力。有光感至能数指的患者愿意用剩余生命中约二分之一的时间,而视力为20/200 - 20/400的患者愿意用剩余生命中约三分之一的时间。
法定盲存在广泛的效用值范围。与有光感至能数指的视力相比,随着感知到的完全失明(双眼无光感),效用值急剧下降,这表明法定盲患者即使保留少量视力对其生活质量和功能发挥也至关重要。