Michaels M G, Jenkins F J, St George K, Nalesnik M A, Starzl T E, Rinaldo C R
Department of Pediatrics, Division of Allergy, Immunology, and Infectious Diseases, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.
J Virol. 2001 Mar;75(6):2825-8. doi: 10.1128/JVI.75.6.2825-2828.2001.
Xenotransplantation is considered to be a solution for the human donor shortage. However, there is a potential risk of transmitting animal infections from the transplanted organ. The known transmissibility and clinical significance of human cytomegalovirus (HCMV) infection after allotransplantation led us to evaluate whether baboon cytomegalovirus (BCMV) transmission could occur after a baboon-to-human liver xenotransplant. We examined serial blood samples from a baboon liver recipient and isolated replication-competent CMV-like agents on days 29, 36, and 42 after xenotransplantation. BCMV and HCMV DNAs were detected in the day 29 isolate, while only HCMV DNA was detected in the other isolates. This is the first report of detecting a replication-competent virus from a source animal after xenotransplantation and is a concern with regard to potential zoonotic transmission to others.
异种移植被认为是解决人类供体短缺的一种方法。然而，移植器官存在传播动物感染的潜在风险。同种异体移植后人类巨细胞病毒（HCMV）感染的已知传播性和临床意义促使我们评估狒狒到人类肝脏异种移植后是否会发生狒狒巨细胞病毒（BCMV）传播。我们检查了一名狒狒肝脏受体的系列血液样本，并在异种移植后第29、36和42天分离出具有复制能力的CMV样病原体。在第29天的分离物中检测到了BCMV和HCMV DNA，而在其他分离物中仅检测到HCMV DNA。这是首次在异种移植后从源动物中检测到具有复制能力病毒的报告，并且这对于潜在的人畜共患病传播给其他人来说是一个问题。
