van Manen J G, Bindels P J, IJzermans C J, van der Zee J S, Bottema B J, Schadé E
Department of General Practice, Division of Public Health, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands.
J Clin Epidemiol. 2001 Mar;54(3):287-93. doi: 10.1016/s0895-4356(01)00346-8.
The goal of this study is to determine the prevalence of 23 common diseases in subjects with a chronic airway obstruction and in controls. All subjects with a known diagnosis by their general practitioner of asthma or chronic obstructive pulmonary disease (COPD), and who were 40 years and older were selected (n = 1145). Subjects who were willing to participate (n = 591) and who appeared to have an irreversible airway obstruction (n = 290) were included. To recruit controls, a random sample was taken of 676 individuals who were 40 years and older and who were not diagnosed as having asthma or COPD by their general practitioner. Of these 676 individuals 421 were willing to participate. The presence of diseases was determined by using a questionnaire. One hundred and ninety-four subjects (73%) and 229 controls (63%) were shown to be suffering from one or more (other) diseases. In both groups, locomotive diseases, high blood pressure, insomnia and heart disease were most common. Locomotive diseases, insomnia, sinusitis, migraine, depression, stomach or duodenal ulcers and cancer were significantly more common in the subject group than in the control group. For both clinical and research purposes, it is important to consider the presence of diseases in patients with a chronic airway obstruction.
本研究的目的是确定慢性气道阻塞患者和对照组中23种常见疾病的患病率。所有经全科医生确诊为哮喘或慢性阻塞性肺疾病（COPD）且年龄在40岁及以上的患者被纳入研究（n = 1145）。愿意参与的患者（n = 591）且似乎存在不可逆气道阻塞的患者（n = 290）被纳入研究。为招募对照组，从676名年龄在40岁及以上且未被全科医生诊断为患有哮喘或COPD的个体中随机抽取样本。在这676名个体中，421名愿意参与。通过问卷调查确定疾病的存在情况。结果显示，194名受试者（73%）和229名对照组（63%）患有一种或多种（其他）疾病。在两组中，运动系统疾病、高血压、失眠和心脏病最为常见。运动系统疾病、失眠、鼻窦炎、偏头痛、抑郁症、胃或十二指肠溃疡以及癌症在受试者组中比对照组更为常见。出于临床和研究目的，考虑慢性气道阻塞患者中疾病的存在情况非常重要。
