Höck A, Demmel U, Schicha H, Kasperek K, Feinendegen L E
Brain. 1975 Mar;98(1):49-64. doi: 10.1093/brain/98.1.49.
Up to 60 tissue samples were dissected from 13 human brains in defined regions and were analysed by means of neutron activation analysis for trace element concentration of cobalt, iron, rubidium, selesium, zinc, chromium, silver, cesium, antimony and scandium. It was shown that the variation in concentration of the non-essential elements in the different brain regions was greater than the corresponding variations in concentration of the essential elements. The mean values of Fe and Rb concentrations were higher in the basal ganglia than in the cortex areas. With increasing age the Fe concentration in the human brain was found to increase and that of Rb to decrease. Comparison of the trace element concentration in corresponding areas of the right and left hemispheres showed highly significant positive correlations for the essential elements. The concentration of each of the essential elements Fe, Rb and Zn was also found to differ significantly between defined functional regions. The characteristic distribution of essential trace elements in different areas is discussed in the light of known metabolic functions of these elements.
从13个人类大脑的特定区域解剖出多达60个组织样本，并通过中子活化分析对钴、铁、铷、硒、锌、铬、银、铯、锑和钪的微量元素浓度进行分析。结果表明，不同脑区非必需元素浓度的变化大于必需元素浓度的相应变化。基底神经节中铁和铷浓度的平均值高于皮质区域。随着年龄的增长，发现人类大脑中铁的浓度增加而铷的浓度降低。左右半球相应区域微量元素浓度的比较显示，必需元素之间存在高度显著的正相关。还发现必需元素铁、铷和锌在特定功能区域之间的浓度也存在显著差异。根据这些元素已知的代谢功能，讨论了必需微量元素在不同区域的特征分布。
