胸苷磷酸化酶和血管内皮生长因子表达在人胃癌中的预后意义
Prognostic significance of expression of thymidine phosphorylase and vascular endothelial growth factor in human gastric carcinoma.
作者信息
Kimura H, Konishi K, Nukui T, Kaji M, Maeda K, Yabushita K, Tsuji M, Miwa A
机构信息
Department of Surgery, Toyama Prefectural Central Hospital, Toyama, Japan.
出版信息
J Surg Oncol. 2001 Jan;76(1):31-6. doi: 10.1002/1096-9098(200101)76:1<31::aid-jso1006>3.0.co;2-9.
BACKGROUND AND OBJECTIVES
Both thymidine phosphorylase (dThdPase) and vascular endothelial growth factor (VEGF) are well-characterized inducers of angiogenesis. The purpose of this study was to examine the expression of these antigens and their prognostic significance in gastric carcinoma.
METHODS
Medical records of 102 patients with stage II tumor were retrospectively reviewed. Primary tumors were studied by immunohistochemical staining for dThdPase and VEGF.
RESULTS
Positive dThdPase expression was observed in 52 (51%) tumors and positive VEGF expression in 53 (52%) tumors. There was a significant correlation between the positive expression of VEGF and lymphatic invasion. The patients with dThdPase-positive carcinoma showed a significantly worse prognosis than those with dThdPase-negative carcinoma in stage II. Moreover, the frequency of hepatic recurrence was significantly higher in the patients with dThdPase-positive and VEGF-positive tumors than in those with dThdPase-negative and VEGF-negative tumors.
CONCLUSIONS
Combination analysis of dThdPase and VEGF expression in gastric carcinoma appears to be well-characterized inductors of prognosis and metastasis.
背景与目的
胸苷磷酸化酶（dThdPase）和血管内皮生长因子（VEGF）都是已被充分表征的血管生成诱导因子。本研究的目的是检测这些抗原在胃癌中的表达及其预后意义。
方法
回顾性分析102例II期肿瘤患者的病历。通过免疫组织化学染色对原发性肿瘤进行dThdPase和VEGF研究。
结果
52例（51%）肿瘤中观察到dThdPase阳性表达，53例（52%）肿瘤中观察到VEGF阳性表达。VEGF阳性表达与淋巴浸润之间存在显著相关性。II期dThdPase阳性癌患者的预后明显比dThdPase阴性癌患者差。此外，dThdPase阳性和VEGF阳性肿瘤患者的肝转移发生率显著高于dThdPase阴性和VEGF阴性肿瘤患者。
结论
胃癌中dThdPase和VEGF表达的联合分析似乎是预后和转移的良好表征诱导因子。
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