血管内皮生长因子表达与人类结直肠癌中肿瘤血管生成、生存率及胸苷磷酸化酶/血小板衍生内皮细胞生长因子表达的相关性
Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer.
作者信息
Amaya H, Tanigawa N, Lu C, Matsumura M, Shimomatsuya T, Horiuchi T, Muraoka R
机构信息
The Second Department of Surgery, Fukui Medical School, Japan.
出版信息
Cancer Lett. 1997 Nov 11;119(2):227-35. doi: 10.1016/s0304-3835(97)00280-2.
To examine the association of vascular endothelial growth factor (VEGF) expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor (dThdPase/PD-ECGF) expression in human colorectal cancer, immunohistochemical studies were performed on 136 cases of resected colorectal cancer specimens using antibodies for VEGF, KDR, CD34 and dThdPase/PD-ECGF. Fifty-nine cases (43%) were evaluated as positive for VEGF staining and 71 cases (52%) were evaluated as positive for dThdPase/PD-ECGF staining. The expression of VEGF correlated significantly with vessel counts and the expression of dThdPase/PD-ECGF (P = 0.01 and 0.01, respectively). Cox proportional hazards model analysis showed that vessel counts and VEGF expression were significant and independent prognostic factors, but that KDR expression was not.
为研究血管内皮生长因子（VEGF）表达与人类结直肠癌肿瘤血管生成、生存及胸苷磷酸化酶/血小板衍生内皮细胞生长因子（dThdPase/PD - ECGF）表达之间的关系，我们使用VEGF、KDR、CD34及dThdPase/PD - ECGF抗体，对136例切除的结直肠癌标本进行了免疫组化研究。59例（43%）VEGF染色呈阳性，71例（52%）dThdPase/PD - ECGF染色呈阳性。VEGF的表达与血管计数及dThdPase/PD - ECGF的表达显著相关（P值分别为0.01和0.01）。Cox比例风险模型分析显示，血管计数和VEGF表达是显著且独立的预后因素，但KDR表达不是。
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